Header text

About clear study

CLEAR = Cancer, Lifestyle & Evaluation of Risk

We need lifestyle information from 12,000 participants: 7,000 people recently diagnosed with cancer, and, if applicable, 5,000 partners. This has been our initial goal, and your input is crucial!

With 12,000 questionnaires completed we aim to investigate many different types of cancer, to provide a better understanding of the causes of cancer in NSW and how these differ in different cultural groups.

Participants are requested to provide an optional blood sample. Combined with the information gained from the questionnaire, the CLEAR study can test current and future gene-environment interactions, which may lead to developing cancer.

Key elements for evaluation are:

  • Physical activity
  • Alcohol consumption
  • Smoking
  • Migration
  • Ethnicity
  • Reproductive history
  • Occupation
  • Screening behaviour
  • Certain dietary patterns

Where will this lead us?

  • With 12,000 participants in the study, results for cancers of the colon and rectum, prostate, breast and lung, melanoma and non-Hodgkin lymphoma will be available.
  • When participation reaches 25,000, enough information will be available to assess the effects of the various genetic and lifestyle factors on the risk of developing liver, thyroid, ovarian and pancreatic cancers.

Let’s help prevent and reduce cancer together. This is your chance to make a difference in the fight against all cancers.

Ultimately, the results of the CLEAR Study will:

  • Enable public health bodies to make better decisions about how best to prevent cancer
  • Provide a better understanding of the multi-factorial causes of cancer in NSW and how these differ in different cultural groups
  • Support better decision-making and prediction of outcomes

If you are interested in participating in the CLEAR study, please click here.

What do we do with collected blood?

Information for CLEAR Study participants

A biobank is a resource for scientists which contain biological samples for research. The biobank at Cancer Council NSW stores blood samples from people with and without cancer for ethically approve public health research.

The Cancer Council NSW Biobank is currently located in the St Vincent’s Hospital  precinct at Darlinghurst, Sydney. It consists of a laboratory where the blood is separated into components (“fractionated”) and a freezer room where numerous ultra-low temperature freezers store the containers (“aliquots”) at -80 degrees Celsius.

The typical donation for CLEAR of 30 mls of blood will usually provide 25 aliquots for storage. Each one of those aliquots will provide sufficient material for numerous tests.
There are up to 48,000 aliquots in each freezer.
We need to know precisely where each aliquot is, and which study participant the aliquot belongs to.
These details are kept in a sophisticated laboratory information management system which records information about the sample, when it was collected and processed and its location.
We take great care to manage our precious collection and have systems in place to ensure its long term safety. 
Our Biobank currently manages the collections from the CLEAR Study. These samples have been collected to enable research into causes of cancer. They will help us identify the differences between people with, and without, cancer and the characteristics of people who have particular types of cancers.
Initial data and samples collected for the CLEAR Study are now available to the research community. The study currently has approximately 10,800 participants and about 8,000 associated sets of blood samples from cases and controls stored in the Biobank.
For further information please contact clearstudyenquiries@nswcc.org.au
Take the survey

Thank you to all the people who have taken part in CLEAR.

Their questionnaire data and blood samples will help us understand risk factors for cancer in NSW.

Freddy SitasAssociate Professor Freddy Sitas

“Many people think the only way to help research is to give a financial donation, but when it comes to a broad reaching study such as CLEAR, we’re totally reliant on the courage and goodwill of cancer patients in the community.”

Karen CanfelAssociate Professor Karen Canfell

“We have an enormous diversity of lifestyles: we can compare and get meaningful answers about the causes of cancer”